E62 BME 461 Protein Structure and Dynamics

This course covers the concepts and methods involved in the analysis of protein structure, stability, folding and misfolding. Topics include protein structural elements, amyloid structure, intra- and intermolecular forces, folding pathways and intermediates, phi-value analysis, kinetics of protein folding and of amyloid formation, and their application to problems of bioengineering and biophysics. Two-thirds of the course will consist of lectures; the other third will be student seminars, in which each student presents a paper from primary literature and its concept and methodology that is discussed in detail. Prerequisites: BME 320B Bioengineering Thermodynamics or equivalent.

Credit 3 units. EN: TU

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