Department of Molecular Microbiology
The Department of Molecular Microbiology teaches introductory courses in microbiology and pathogenic microorganisms for first-year medical students and graduate students. In conjunction with the Division of Biology & Biomedical Sciences (DBBS) program in Molecular Microbiology and Microbial Pathogenesis, the department also offers a number of advanced courses that are primarily designed for graduate students but also open to medical students. Advanced elective research activities are offered by faculty in the department.
| Website: | http://www.microbiology.wustl.edu |
Sean P. J. Whelan, PhD
Department Chair
Christina L. Stallings, PhD
Program Director
Visit our website for more information about our faculty and their appointments.
B
Wandy L. Beatty, Ph.D.
Associate Professor of Molecular Microbiology (primary appointment)
Bachelor of Science, Montana State University, 1989
Doctor of Philosophy, University of Wisconsin Madison, 1994
Douglas E Berg, Ph.D.
Alumni Professor Emeritus of Molecular Microbiology
Bachelor of Science, Cornell University, 1964
Doctor of Philosophy, University of Washington, 1969
Stephen M Beverley, Ph.D.
Professor of Molecular Microbiology (primary appointment)
Ernest St. John Simms Distinguished Professor of Molecular Microbiology
Bachelor of Science, California Institute Technology, 1973
Doctor of Philosophy, University of California, 1979
Tamara L. Brent, Ph.D., M.D.
Professor of Molecular Microbiology (primary appointment)
Alumni Endowed Professor of Molecular Microbiology
Bachelor of Arts, Johns Hopkins University, 1983
Doctor of Philosophy, Johns Hopkns University Medical, 1991
Doctor of Medicine, Johns Hopkns University Medical, 1991
Anne Elizabeth Mayer Bridwell, D.V.M., Ph.D.
Instructor in Molecular Microbiology (primary appointment)
Bachelor of Arts, Kenyon College, 2003
Doctor of Veterinary Medicine, Virginia Tech, 2009
Doctor of Philosophy, Wake Forest University, 2015
C
Michael G Caparon, Ph.D.
Professor of Molecular Microbiology (primary appointment)
Bachelor of Science, Michigan State University, 1981
Doctor of Philosophy, University of Iowa, 1985
D
Gisela Andrea Di Venanzio, Ph.D.
Instructor in Molecular Microbiology (primary appointment)
Doctor of Philosophy, Rosario National University, 2014
Siyuan Ding, Ph.D.
Assistant Professor of Molecular Microbiology (primary appointment)
Bachelor of Science, Fudan University, 2009
Doctor of Philosophy, Yale University, 2014
Deborah E Dobson, Ph.D.
Associate Professor of Molecular Microbiology (primary appointment)
Champaign, 1976
Doctor of Philosophy, University of California Berkeley, 1981
Karen W Dodson, Ph.D.
Instructor in Molecular Microbiology (primary appointment)
Bachelor of Arts, University of Missouri Columbia, 1983
Doctor of Philosophy, Washington University in St Louis, 1990
F
Mario Federico Feldman, Ph.D.
Professor of Molecular Microbiology (primary appointment)
Doctor of Philosophy, Universidad del Buenos Aires, 2004
Julian B Fleischman, Ph.D.
Associate Professor Emeritus of Molecular Microbiology
Bachelor of Science, Yale University, 1955
Doctor of Philosophy, Harvard University, 1960
H
Henry V Huang, Ph.D.
Associate Professor of Molecular Microbiology (primary appointment)
Bachelor of Arts, Occidental College, 1972
Doctor of Philosophy, California Institute Technology, 1977
Scott James Hultgren, Ph.D.
Professor of Molecular Microbiology (primary appointment)
Helen L Stoever Professor of Molecular Microbiology
Bachelor of Science, Indiana University Bloomington, 1981
Doctor of Philosophy, Northwestern University, 1987
K
Sebla Bulent Kutluay, Ph.D.
Assistant Professor of Molecular Microbiology (primary appointment)
Doctor of Philosophy, Michigan State University, 2009
L
Michele LeRoux, Ph.D.
Assistant Professor of Molecular Microbiology (primary appointment)
null, Colgate University, 2007
null, University of Washington, 2015
Zhuoming Liu, Ph.D.
Instructor in Molecular Microbiology (primary appointment)
Doctor of Philosophy, University of Tokyo, 2015
Jennifer K Lodge, Ph.D.
Professor of Molecular Microbiology (primary appointment)
Bachelor of Science, Oberlin College, 1979
Doctor of Philosophy, Washington University in St Louis, 1988
Carolina Beatriz Lopez, M.S., Ph.D.
Professor of Molecular Microbiology (primary appointment)
Bachelor of Science, Pontificia Universidad Catolica, 1992
Master of Science, Pontificia Universidad Catolica, 1995
Doctor of Philosophy, Mount Sinai School of Medicine, 2002
O
Paul D Olivo, Ph.D., M.D.
Adjunct Assistant Professor of Molecular Microbiology
Bachelor of Arts, George Washington University, 1972
Doctor of Medicine, University of Florida, 1981
Doctor of Philosophy, University of Florida, 1982
R
Charles M Rice, Ph.D.
Adjunct Professor of Molecular Microbiology
Bachelor of Science, University of California, 1974
Doctor of Philosophy, California Institute Technology (Duplicate of California Institute of Technology), 1981
S
Sondra Schlesinger, Ph.D.
Professor Emerita of Molecular Microbiology
Bachelor of Science, University of Michigan (Duplicate of University of Michigan Ann Arbor), 1956
Doctor of Philosophy, University of Michigan (Duplicate of University of Michigan Ann Arbor), 1960
Henry L Schreiber, M.S., Ph.D.
Instructor in Molecular Microbiology (primary appointment)
null, Tyler Junior College, 2004
null, Tulane University, 2008
null, University of Texas Tyler, 2011
null, Washington University in St Louis, 2017
Laurence David Sibley, Ph.D.
Professor of Molecular Microbiology (primary appointment)
Alan A and Edith L Wolff Distinguished Professor
Bachelor of Arts, Oberlin College, 1978
Doctor of Philosophy, Louisiana State University, 1985
Asya Smirnov, D.V.M., Ph.D.
Instructor in Molecular Microbiology (primary appointment)
Doctor of Veterinary Medicine, Moscow Veterinary Academy, 1993
Doctor of Philosophy, Hebrew University, 2005
Christina Leigh Stallings, M.A., M.S., Ph.D.
Professor of Molecular Microbiology (primary appointment)
Bachelor of Science, Mary Washington College, 1999
Master of Arts, Columbia University, 2001
Master of Science, Columbia University, 2002
Doctor of Philosophy, Columbia University, 2005
Patrick Michael Stuart, M.S., Ph.D.
Associate Professor of Molecular Microbiology
Adjunct Instructor
Lecturer
Bachelor of Science, University of California, 1974
Master of Science, California State University, 1980
Doctor of Philosophy, Northwestern University, 1985
T
Niraj Harish Tolia, Ph.D.
Adjunct Assoicate Professor of Molecular Microbiology
Bachelor of Science, Imperial College, 1999
Doctor of Philosophy, Watson School of Biological Sciences, 2004
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Joseph Paul Vogel, Ph.D.
Associate Professor of Molecular Microbiology (primary appointment)
Bachelor of Science, Minnesota State University, 1986
Doctor of Philosophy, Princeton University, 1993
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David Wang, Ph.D.
Professor of Molecular Microbiology (primary appointment)
Professor of Pathology and Immunology
Bachelor of Science, Stanford University, 1992
Doctor of Philosophy, Massachusetts Institute of Technology, 1998
Sean P. J. Whelan, Ph.D.
Professor of Molecular Microbiology (primary appointment)
Head of the Department of Molecular Microbiology
Marvin A Brennecke Distinguished Professor of Molecular Microbiology
Doctor of Philosophy, Reading University, 1993
Molecular Microbiology Research Electives
During the fourth year, opportunities exist for many varieties of advanced clinical or research experiences.
Stephen M. Beverley, PhD
McDonnell Pediatric Research Building, 9th Floor
Phone: 314-747-2630
Molecular genetics of protozoan parasites and tropical diseases; biosynthesis of the parasite surface, genomics, virulence and drug action or resistance.
Michael Caparon, PhD
McDonnell Pediatric Research Building, 10th Floor
Phone: 314-362-1485
Molecular genetics and pathogenicity of the streptococci and other pathogenic gram-positive bacteria.
Siyuan Ding, PhD
McDonnell Pediatric Research Building, 9th Floor
Phone: 314-273-3963
Molecular mechanisms of rotavirus replication and pathogenesis; virus-host interactions; innate immune signaling in the intestinal epithelium.
Tamara L. Doering, MD, PhD
McDonnell Pediatric Research Building, 10th Floor
Phone: 314-747-5597
The Doering lab studies the opportunistic fungal pathogen Cryptococcus neoformans, with the dual motivations of elucidating basic biology and identifying potential drug targets. Projects include studies of the synthesis and regulation of the main cryptococcal virulence factor, its polysaccharide capsule, and host-fungal interactions. Current approaches include those of biochemistry, cell and molecular biology, and genetics; studies also include high-throughput analysis of host-pathogen interactions and computational approaches to reconstructing the capsule regulatory network.
Daniel Goldberg, MD, PhD
McDonnell Pediatric Research Building, 9th Floor
Phone: 314-362-1514
Biochemistry of malaria.
Henry Huang, PhD
McDonnell Pediatric Research Building, 8th Floor
Phone: 314-362-2755
RNA virus evolution; molecular biology of alphaviruses; alphavirus gene expression vectors; antiviral drug design.
Scott J. Hultgren, PhD
McDonnell Pediatric Research Building, 10th Floor
Phone: 314-362-6772
Our focus is on the pathogenic mechanisms and disease outcomes in the urinary tract. Work in the Hultgren lab blends multiple scientific disciplines to elucidate bacterial and host mechanisms that determine the onset, course and outcome of interactions between a host mucosal surface and bacterial pathogens. Using genetics, genomics, biochemistry, structural biology, high-resolution imaging, animal models, clinical studies and combinatorial chemistry, we have illuminated new ways in which intracellular lifestyles and community behavior play critical roles in the pathogenesis of urinary tract infection. We have uncovered new principles of adhesive pili biogenesis in gram-negative bacteria by the chaperone/usher pathway, delineating the fine molecular details of a donor strand complementation and exchange mechanism by which the energy of final subunit folding is used to complete the assembly and extrusion of pili across the outer membrane. We revealed how uropathogenic Escherichia coli use type 1 pili to invade and establish biofilm-like intracellular bacterial communities within bladder cells as part of a mechanism that subverts host defenses and how quiescent intracellular reservoirs can seed recurrent infections. We have uncovered complex networks that govern mucosal epithelial response to infection, which we have shown determines disease outcome. Further, we have made seminal contributions to our understanding of the pathogenesis and response to other uropathogens, polymicrobial infections and catheter-associated UTIs and to the mechanisms by which bacteria form a directed amyloid fiber, curli, which is important in biofilm formation. Together, this work is changing the way UTIs are evaluated, reshaping models of bacterial infections in general and spawning new technologies to design novel vaccines and antimicrobial therapeutics to diagnose, treat and/or prevent UTIs and their sequelae.
Christina L. Stallings, PhD
McDonnell Pediatric Research Building, 8th Floor
Phone: 314-286-0276
Our main focus is the molecular pathogenesis of mycobacteria. Our laboratory integrates in vivo disease modeling, molecular biology and biochemistry to provide answers to the fundamental biological questions regarding molecular pathogenesis and to yield therapeutic strategies for the treatment of mycobacterial infections.
Joseph P. Vogel, PhD
McDonnell Pediatric Research Building, 10th Floor
Phone: 314-747-1029
Legionella pneumophila, the causative agent of Legionnaires' pneumonia, replicates inside alveolar macrophages by preventing phagosome-lysosome fusion.
David Wang, PhD
McDonnell Pediatric Research Building, 8th Floor
Phone: 314-286-1123
Our work focuses on the discovery and characterization of novel viruses. We use functional genomic technologies to identify novel viruses from a variety of clinical samples from diseases of unexplained etiology. We then use epidemiologic, molecular and cellular strategies to define the relevance of newly identified viruses to human disease. A range of new viruses — including polyomaviruses, astroviruses and picronaviruses — are currently under investigation.
Sean P.J. Whelan, PhD
McDonnell Pediatric Research Building, 9th Floor
Phone: 314-286-1585
The Whelan Lab research focus is on the molecular mechanisms that underpin gene expression in nonsegmented negative-strand (NNS) RNA viruses — a group of viruses that includes some of the most significant human pathogens in existence (e.g., rabies, ebola, respiratory syncytial virus, measles, mumps, Nipah viruses). Vesicular stomatitis virus (VSV) has served as an important prototype of the NNS RNA viruses for more than 50 years, and Dr. Whelan has played a leading role in this field that can be traced back to the recovery of infectious virus from cDNA. As independent investigators, Dr. Whelan and his colleagues have led the way to understanding the structure and function of the viral replication machinery. The goals of such studies have been to ultimately inform the development of inhibitors against this group of important pathogens and to advance the use of VSV as a vaccine vector, an oncolytic agent, and a neuronal tracer.
Visit online course listings to view offerings for M30 MolMB.
M30 MolMB 526 Microbes and Pathogenesis
The course will familiarize the student with the diversity of pathogenic microbes and the different ways they can survive and cause disease. It is a concepts-based course, emphasizing the general principles of microbial pathogenesis. Selected pathogenic microbes are used as models to describe pathogen-host interactions in molecular detail. The laboratory will introduce the student to the principles and the basic techniques of diagnostic bacteriology.
Credit 30 units.
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M30 MolMB 900 Research Elective - Molecular Microbiology
Research opportunities may be available. If interested, please contact the Department of Molecular Microbiology.
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