The Department of Genetics is at the forefront of the rapidly developing field known as genomic (or personalized) medicine, in which genetic and epigenetic analysis coupled with clinical information enables treatments to be tailored specifically to the individual patient. The rapid evolution of sequencing technologies, genome engineering, automated cellular imaging and mass spectrometry methods to rapidly perform proteomic and metabolomics studies, coupled with powerful computational tools, is revolutionizing the biological sciences. Investigators in the department are developing new methods of genomic analysis — including technology and software, epigenomics and copy number variation as well as studies of disease pathways using model organisms — to identify and study the genes responsible for human disease and treatment responses.
The department supports a broad program of preclinical and graduate instruction in genetics, with research opportunities that include studies of transcriptional networks, population genetics, protein evolution, neurological disorders, developmental genetics, models of human disease, genome architecture, statistical genetics and computational biology, genome technologies and infertility.
A significant portion of the first-year course in basic medical sciences is devoted to human and clinical genetics, with emphasis on how genomic information will transform the practice of medicine. This includes specialized selective courses in addition to the core genetic curriculum. Advanced training in clinical genetics and in genetic research is available from the faculty in the Department of Genetics and from geneticists with principal appointments in many other departments within the School of Medicine.
Advanced courses and seminars are offered that focus on the genetics of complex disease, gene expression, genome engineering, induced pluripotent stem cells, single-cell genomics, molecular genetics, genetic epidemiology, computational biology, developmental genetics, microbial genetics, cancer genetics, and population and evolutionary genetics. Extraordinary opportunities for research training and experience are available in all of these areas and at all levels. The programs are tailored to meet the needs of medical students, graduate students, and both MD and PhD postdoctoral fellows pursuing advanced training in biomedical research.
Although the Department of Genetics does not offer its own degree, some of the department's courses are open to students in the MD and MSTP (MD/PhD) programs. Further information about the MD and MSTP degrees can be found in the Degrees & Programs section of this Bulletin.
M20 Genetics 900
Cross-listed with L41 Biol 590
Barak Cohen, PhD
Couch Biomedical Research Building, Room 4308
Functional genomics in yeast; gene regulatory networks, complex trait genetics, and synthetic biology studies of cis-regulation.
Joseph Dougherty, PhD
Couch Biomedical Research Building, Room 6316
Our laboratory utilizes a variety of techniques spanning from human molecular genetics and informatics to mouse behavioral neuroscience and neuroanatomy. We develop and employ mouse models of psychiatric disorders, particularly those that mimic genetic variations that we have identified in human patient populations, with the goal of trying to understand the cellular and molecular underpinnings of these disorders.
Susan K. Dutcher, PhD
Couch Biomedical Research Building, Room 5301
Studies of the role of centrioles and basal bodies in ciliary signaling, assembly, and motility using molecular genetics and computational and biochemical approaches.
Heather Lawson, PhD
Couch Biomedical Research Building, Room 6312
Our lab focuses on translating genetic and epigenetic molecular and analytical observations to physiological endpoints. We apply several complementary and integrated approaches, including bench science, cultured cells, mouse phenotyping and husbandry, and computational and systems biology.
Jeffrey Milbrandt, MD, PhD
Couch Biomedical Research Building, Room 6306
We are performing Cas9/CRISPR activation and repression screens in iPSC-derived neurons together with single-cell transcriptomics analysis to evaluate the causal effects of genetic variants associated with neuropsychiatric diseases. We are also studying how metabolism influences the axonal/glial interactions important for proper nerve function. We use genetic and metabolomic analysis to identify molecular mechanisms of axonal degeneration, a self-destructive process that plays an important role in many neurodegenerative conditions.
Rob Mitra, PhD
Couch Biomedical Research Building, Room 4301
Our focus is on systems biology, gene regulation and technology development. Projects in the lab fall into three general categories: (1) understanding the molecular logic of transcription factor cooperativity; (2) mapping the gene regulatory networks that control developmental processes and using this knowledge to reprogram fibroblasts into useful cell types; and (3) developing novel technologies to more efficiently achieve the first two aims.
Samantha Morris, PhD
Couch Biomedical Research Building, Room 3316
This lab strives to engineer cell fate to generate clinically valuable cell populations via stem cell and developmental biology. Our research focuses on dissecting the gene regulatory networks that define cell identity, using the developing embryo and tissue regeneration as a guide to engineer fate in vitro. We apply insight from these analyses to generate clinically relevant populations by differentiating cells from a pluripotent state or by directly converting cells between mature fates. We employ a combination of computational, single-cell transcriptomics with cell and developmental biology approaches.
Zachary Pincus, PhD
Couch Biomedical Research Building, Room 5304
Interindividual variability in aging and lifespan; developmental origins of longevity and adult health; quantitative microscope and image analysis of C. elegans.
Michael A. Province, PhD
Farrell Learning and Teaching Center (FLTC), 6th floor, Suite 605
Development and evaluation of novel statistical genetics methodology, especially as applied to genomic identification and validation of variants for human complex quantitative traits, such as heart disease, cancer, pulmonary function, diabetes and human longevity.
Nancy L. Saccone, PhD
Farrell Learning and Teaching Center (FLTC), 6th floor, Suite 606
Statistical genetics and psychiatric genetics; development and application of analysis methods for studying the genetics of human disease and complex traits.
Tim Schedl, PhD
Couch Biomedical Research Building, Room 5305
Our lab studies germ cell development in the model organism Caenorhabditis elegans. The major focuses are control of the decision to proliferate or enter the meiotic pathway, control and coordination of meiotic prophase progression and gametogenesis, and control of meiotic maturation and ovulation.
James Skeath, PhD
Couch Biomedical Research Building, Room 6315
Identification of the genes and the elucidation of the molecular mechanisms that regulate the early events of Drosophila central neurogenesis; illumination of the mechanisms that form, pattern and specify the individual identities of the progenitor cells of the Drosophila embryonic central nervous system.
Gary D. Stormo, PhD
Couch Biomedical Research Building, Room 4208
Computational biology of protein-DNA interactions, RNA folding, gene and promoter finding; biochemical analysis of DNA-protein interactions and gene regulation.
Ting Wang, PhD
Couch Biomedical Research Building, Room 5211
We work in the general field of computational genomics and epigenomics. We study the evolution of human regulatory networks, with a focus on mobile elements (or transposable elements) and their impact on gene regulation, their genetic and epigenetic control, and their roles in human biology and diseases.
Visit online course listings to view offerings for M20 Genetics.
M20 Genetics 511 Medical Genetics
Medical genetics is both a science and a clinical area or specialty of medicine, and the boundary between research and clinical application is increasingly blurred. The pace at which genomic and epigenomic tools are being developed is unprecedented. These tools result in continual conceptual advancements, which inevitably affect how we approach the study of disease risk, diagnosis, and management in all areas of medicine, not just medical genetics. We are moving into a time when the interpretable data from the examination of individual genomes will be incorporated into all other clinical data to assess individual risks and to guide clinical management and decision making. This course is intended as the first step toward life-long training in medical genetics and genomics. The course begins with a number of sessions devoted to basic principles of genetics. Drawing on this foundation, we move on to discuss genomic and epigenomic tools, to learn from leaders in their fields about the big questions in genetics and genomics (e.g., microbiome research, cancer genomics, current clinical uses of exome sequencing), and to discover how the tools are being used to answer these questions. Students are exposed to the use of genetic and genomic databases and information resources, which will allow them to keep up with new information and to critically appraise its validity and clinical utility. We begin to discuss the implication of this shift to the "genomic era," particularly regarding ethical aspects, regulatory aspects, equal access, healthcare costs, and patient education. Clinical geneticists actively participate in the course and use a series of genetic disorders to help students apply their knowledge, focusing mainly on genetic etiology, pattern of inheritance, inheritance risk, and molecular diagnostic testing. Frequent patient interviews further enhance the exposure to clinical genetics. Overall, the course aims to enhance genetic and genomic literacy, which is an essential first step in preparing students to participate in the multidisciplinary teams that effectively make cutting-edge genetic and genomic research results accessible to patients. This course is cross-listed with L41 Biol 550.
Credit 34 units.